R\u00f6vid le\u00edr\u00e1s<\/strong><\/span>
A r\u00e1kgy\u00f3gy\u00e1szatban eredm\u00e9nnyel alkalmazhat\u00f3 tal\u00e1lm\u00e1ny t\u00e1rgy\u00e1t k\u00e9pez\u0151 7-es poz\u00edci\u00f3hoz kapcsol\u00f3d\u00f3 3,5-diszubsztitu\u00e1lt benzilcsoportot tartalmaz\u00f3 \u00faj imipridon-sz\u00e1rmaz\u00e9k hat\u00f3anyagok k\u00fcl\u00f6n\u00f6sen a prosztatakarcin\u00f3m\u00e1ban, hasny\u00e1lmirigyr\u00e1kban, t\u00fcd\u0151karcin\u00f3m\u00e1ban, eml\u0151r\u00e1kban, vastagb\u00e9lr\u00e1kban, b\u0151rr\u00e1kban, gliom\u00e1ban, fej-nyaki daganatokban szenved\u0151 betegekn\u00e9l fejtenek ki fokozott r\u00e1kellenes aktivit\u00e1st. A tal\u00e1lm\u00e1ny t\u00e1rgya (I) (I) \u00e1ltal\u00e1nos k\u00e9plet\u0171 vegy\u00fcletek vagy gy\u00f3gy\u00e1szatilag elfogadhat\u00f3 s\u00f3ik \u00e9s sztereoizomerjeik, amelyek alkalmasak r\u00e1kbetegs\u00e9gek kezel\u00e9s\u00e9re. A tal\u00e1lm\u00e1ny t\u00e1rgy\u00e1t k\u00e9pezi tov\u00e1bb\u00e1 a fenti vegy\u00fcleteket tartalmaz\u00f3 gy\u00f3gy\u00e1szati k\u00e9sz\u00edtm\u00e9ny.<\/p>\n[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner _builder_version=”4.18.1″ custom_margin=”||0px||false|false” custom_padding=”||0px||false|false” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_button button_url=”mailto:info@danubia.hu” button_text=”Kapcsolat” button_alignment=”left” module_class=”gq_r_fixed_buttons” _builder_version=”4.18.1″ custom_button=”on” button_text_size=”16″ button_text_color=”#ffffff” button_bg_color=”#a6192e” button_border_color=”#a6192e” button_font=”Raleway|600||on|||||” button_icon=”9||divi||400″ animation_style=”fade” hover_enabled=”0″ z_index_tablet=”500″ global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner _builder_version=”4.16″ custom_margin=”0px||||false|false” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”4.16″ global_colors_info=”{}”][et_pb_button button_url=”https:\/\/www.danubia.com\/hu\/danubia-ipmall\/#piacter” button_text=”Vissza a szellemitulajdon-piact\u00e9rre” button_alignment=”left” module_class=”gq_r_fixed_buttons” _builder_version=”4.16″ custom_button=”on” button_text_size=”16″ button_text_color=”#a6192e” button_bg_color=”#ffffff” button_border_color=”#a6192e” button_font=”Raleway|600||on|||||” button_icon=”9||divi||400″ button_icon_color=”#a6192e” animation_style=”fade” z_index_tablet=”500″ global_colors_info=”{}” button_bg_color__hover_enabled=”on|desktop” button_bg_color__hover=”#ffffff”][\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
A r\u00e1kgy\u00f3gy\u00e1szatban eredm\u00e9nnyel alkalmazhat\u00f3 tal\u00e1lm\u00e1ny t\u00e1rgy\u00e1t k\u00e9pez\u0151 7-es poz\u00edci\u00f3hoz kapcsol\u00f3d\u00f3 3,5-diszubsztitu\u00e1lt benzilcsoportot tartalmaz\u00f3 \u00faj imipridon-sz\u00e1rmaz\u00e9k hat\u00f3anyagok k\u00fcl\u00f6n\u00f6sen a prosztatakarcin\u00f3m\u00e1ban, hasny\u00e1lmirigyr\u00e1kban, t\u00fcd\u0151karcin\u00f3m\u00e1ban, eml\u0151r\u00e1kban, vastagb\u00e9lr\u00e1kban, b\u0151rr\u00e1kban, gliom\u00e1ban, fej-nyaki daganatokban szenved\u0151 betegekn\u00e9l fejtenek ki fokozott r\u00e1kellenes aktivit\u00e1st.<\/p>\n","protected":false},"author":1,"featured_media":9539,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"
[et_pb_section fb_built=\"1\" specialty=\"on\" _builder_version=\"3.22\" inner_max_width=\"none\"][et_pb_column type=\"1_4\" _builder_version=\"3.25\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_image src=\"https:\/\/www.danubia.com\/wp-content\/uploads\/2021\/08\/Valos-ideju-fluoreszcencia-alapu-vizsgalat-az-OATP-transzporterek-funkcionalis-tesztelesehez-es-gyogyszer-kolcsonhatasainak-vizsgalatahoz.jpg\" title_text=\"Valos ideju fluoreszcencia alapu vizsgalat az OATP-transzporterek funkcionalis tesztelesehez es gyogyszer-kolcsonhatasainak vizsgalatahoz\" align_tablet=\"center\" align_phone=\"\" align_last_edited=\"on|desktop\" _builder_version=\"4.9.4\" custom_margin=\"||0px|\" custom_padding=\"||15px|\" animation_style=\"fade\" hover_enabled=\"0\" z_index_tablet=\"500\" sticky_enabled=\"0\"][\/et_pb_image][\/et_pb_column][et_pb_column type=\"3_4\" specialty_columns=\"3\" _builder_version=\"3.25\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_row_inner admin_label=\"Sor\" _builder_version=\"3.25\"][et_pb_column_inner saved_specialty_column_type=\"3_4\" _builder_version=\"3.25\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text admin_label=\"N\u00e9v\" _builder_version=\"4.9.4\" text_font=\"Raleway|700||on|||||\" text_text_color=\"#a6192e\" text_font_size=\"26px\" text_line_height=\"1.3em\" header_font=\"Raleway|700||on|||||\" header_text_align=\"center\" header_text_color=\"#ffffff\" header_font_size=\"50px\" header_line_height=\"1.4em\" custom_margin=\"||0px|\" custom_padding=\"||15px|\" hover_enabled=\"0\" text_font_size_tablet=\"22px\" text_font_size_phone=\"20px\" text_font_size_last_edited=\"on|phone\" header_font_size_tablet=\"30px\" header_font_size_phone=\"22px\" header_font_size_last_edited=\"on|desktop\" z_index_tablet=\"500\" sticky_enabled=\"0\"]Val\u00f3s idej\u0171 fluoreszcencia alap\u00fa vizsg\u00e1lat az OATP-transzporterek funkcion\u00e1lis tesztel\u00e9s\u00e9hez \u00e9s gy\u00f3gyszer-k\u00f6lcs\u00f6nhat\u00e1sainak vizsg\u00e1lat\u00e1hoz[\/et_pb_text][et_pb_text admin_label=\"Bejelent\u00e9s \u00fcgysz\u00e1ma, Lajstromsz\u00e1m\" _builder_version=\"4.9.4\" text_font=\"Raleway|700|||||||\" text_text_color=\"#63666a\" text_font_size=\"18px\" custom_margin=\"||0px|\" custom_padding=\"||10px|\" hover_enabled=\"0\" text_font_size_tablet=\"20px\" text_font_size_phone=\"\" text_font_size_last_edited=\"on|desktop\" z_index_tablet=\"500\" sticky_enabled=\"0\"]<\/p>
Reprezentat\u00edv \u00fcgysz\u00e1m: WO\/2021\/123851
Oltalom: Szabadalom
Ipar\u00e1g: gy\u00f3gyszer \u00e9s kozmetikai ipar<\/p>
[\/et_pb_text][et_pb_divider divider_position=\"center\" divider_weight=\"3\" _builder_version=\"4.4.8\" max_width=\"50px\" module_alignment=\"left\" height=\"0px\" animation_style=\"zoom\" z_index_tablet=\"500\"][\/et_pb_divider][et_pb_text admin_label=\"Le\u00edr\u00e1s\" _builder_version=\"4.9.4\" text_orientation=\"justified\" hover_enabled=\"0\" z_index_tablet=\"500\" sticky_enabled=\"0\"]<\/p>
R\u00f6vid le\u00edr\u00e1s<\/strong><\/span>
A tal\u00e1lm\u00e1ny az OATP (szerves aniont sz\u00e1ll\u00edt\u00f3 polipeptid) transzportfeh\u00e9rj\u00e9k transzportaktivit\u00e1s\u00e1nak \u00e9rt\u00e9kel\u00e9s\u00e9re, k\u00fcl\u00f6n\u00f6sen egy val\u00f3s idej\u0171, add-and-read fluoreszcencia-alap\u00fa elj\u00e1r\u00e1sra vonatkozik, mely annak meghat\u00e1roz\u00e1s\u00e1ra szolg\u00e1l, miszerint a tesztvegy\u00fclet befoly\u00e1solja-e az OATP szubsztr\u00e1ttranszport-aktivit\u00e1s\u00e1t. Az elj\u00e1r\u00e1s egy nem fluoreszcens kontroll szubsztr\u00e1t alkalmaz\u00e1s\u00e1val val\u00f3sul meg, amely a sejtben fluoreszcens tulajdons\u00e1got mutat fel. A m\u00f3dszer alkalmazhat\u00f3 az OATP expresszi\u00f3j\u00e1nak m\u00e9r\u00e9s\u00e9re \u00e9s a sz\u00e1ll\u00edtott szubsztr\u00e1t valamint az OATP inhibitor k\u00f6z\u00f6tti k\u00fcl\u00f6nbs\u00e9gt\u00e9telre is.<\/p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=\"1_2,1_2\" _builder_version=\"4.4.8\" custom_margin=\"||0px||false|false\" custom_padding=\"||0px||false|false\"][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"3_4\" _builder_version=\"4.4.8\"][et_pb_button button_url=\"https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2021123851\" url_new_window=\"on\" button_text=\"Tov\u00e1bbi inform\u00e1ci\u00f3k\" button_alignment=\"left\" module_class=\"gq_r_fixed_buttons\" _builder_version=\"4.9.4\" custom_button=\"on\" button_text_size=\"16\" button_text_color=\"#ffffff\" button_bg_color=\"#a6192e\" button_border_color=\"#a6192e\" button_font=\"Raleway|600||on|||||\" button_icon=\"%%24%%\" animation_style=\"fade\" hover_enabled=\"0\" z_index_tablet=\"500\" sticky_enabled=\"0\"][\/et_pb_button][\/et_pb_column_inner][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"3_4\" _builder_version=\"4.4.8\"][et_pb_button button_url=\"mailto:info@danubia.hu\" button_text=\"Kapcsolatfelv\u00e9tel\" button_alignment=\"right\" module_class=\"gq_r_fixed_buttons\" _builder_version=\"4.9.4\" custom_button=\"on\" button_text_size=\"16\" button_text_color=\"#ffffff\" button_bg_color=\"#a6192e\" button_border_color=\"#a6192e\" button_font=\"Raleway|600||on|||||\" button_icon=\"%%24%%\" animation_style=\"fade\" z_index_tablet=\"500\"][\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner _builder_version=\"4.4.8\" custom_margin=\"0px||||false|false\"][et_pb_column_inner saved_specialty_column_type=\"3_4\" _builder_version=\"4.4.8\"][et_pb_button button_url=\"https:\/\/www.danubia.com\/hu\/danubia-ipmall\/#piacter\" button_text=\"Vissza a szellemitulajdon-piact\u00e9rre\" button_alignment=\"left\" module_class=\"gq_r_fixed_buttons\" _builder_version=\"4.4.8\" custom_button=\"on\" button_text_size=\"16\" button_text_color=\"#a6192e\" button_bg_color=\"#ffffff\" button_border_color=\"#a6192e\" button_font=\"Raleway|600||on|||||\" button_icon=\"%%24%%\" button_icon_color=\"#a6192e\" animation_style=\"fade\" z_index_tablet=\"500\" button_bg_color__hover_enabled=\"on|desktop\"][\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section]<\/p>","_et_gb_content_width":"","footnotes":""},"project_category":[172,186],"project_tag":[],"class_list":["post-9537","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-gyogyszeripar-es-kozmetikai-ipar","project_category-pharmaceutical-and-cosmetics-industry"],"yoast_head":"\n
R\u00e1kellenes imipridon sz\u00e1rmaz\u00e9kok - Danubia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.danubia.com\/ipmall\/synthesis-of-novel-imipridone-derivatives-and-their-evaluation-for-their-anticancer-activity\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"R\u00e1kellenes imipridon sz\u00e1rmaz\u00e9kok - Danubia\" \/>\n<meta property=\"og:description\" content=\"A r\u00e1kgy\u00f3gy\u00e1szatban eredm\u00e9nnyel alkalmazhat\u00f3 tal\u00e1lm\u00e1ny t\u00e1rgy\u00e1t k\u00e9pez\u0151 7-es poz\u00edci\u00f3hoz kapcsol\u00f3d\u00f3 3,5-diszubsztitu\u00e1lt benzilcsoportot tartalmaz\u00f3 \u00faj imipridon-sz\u00e1rmaz\u00e9k hat\u00f3anyagok k\u00fcl\u00f6n\u00f6sen a prosztatakarcin\u00f3m\u00e1ban, hasny\u00e1lmirigyr\u00e1kban, t\u00fcd\u0151karcin\u00f3m\u00e1ban, eml\u0151r\u00e1kban, vastagb\u00e9lr\u00e1kban, b\u0151rr\u00e1kban, gliom\u00e1ban, fej-nyaki daganatokban szenved\u0151 betegekn\u00e9l fejtenek ki fokozott r\u00e1kellenes aktivit\u00e1st.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.danubia.com\/ipmall\/synthesis-of-novel-imipridone-derivatives-and-their-evaluation-for-their-anticancer-activity\/\" \/>\n<meta property=\"og:site_name\" content=\"Danubia\" \/>\n<meta property=\"article:modified_time\" content=\"2022-11-29T22:21:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.danubia.com\/wp-content\/uploads\/2022\/03\/Rakellenes-imipridon-szarmazekok-2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1080\" \/>\n\t<meta property=\"og:image:height\" content=\"810\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Becs\u00fclt olvas\u00e1si id\u0151\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 perc\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.danubia.com\\\/ipmall\\\/synthesis-of-novel-imipridone-derivatives-and-their-evaluation-for-their-anticancer-activity\\\/\",\"url\":\"https:\\\/\\\/www.danubia.com\\\/ipmall\\\/synthesis-of-novel-imipridone-derivatives-and-their-evaluation-for-their-anticancer-activity\\\/\",\"name\":\"R\u00e1kellenes imipridon sz\u00e1rmaz\u00e9kok - 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