Rövid leírás
A Tavanta Therapeutics Zrt. innovációra épülő specializált gyógyszercég portfóliójában számos klinikai vizsgálati fázisban lévő gyógyszerhatóanyag-jelöltet fejleszt annak céljából, hogy (i) javítsa a gyógyszerhatóanyagok klinikai hatásosságát, és (ii) új kis molekulás hatóanyagokat és terápiás peptideket állítson elő a betegségek hatékonyabb kezelése céljából. Szakmai partnerek szakértelmére támaszkodva a vállalat folyamatosan új fejlesztési projekteket keres, különösen a következő területeken: (i) új (originális) gyógyszerhatóanyag-jelölt molekulák licenciája, (ii) ritka betegségek (rare/orphan diseases) kezelését célzó vizsgálati fázisú gyógyszerhatanyag-jelöltek licenciája, (iii) forgalomba hozatali engedéllyel rendelkezőgyógyszerek új alkalmazási indikációja, (iv) forgalomba hozatali engedéllyel rendelkező gyógyszerek biológiai hatásosságának javítása. A vállalat a K+F folyamat bármely szakaszában lévő – azaz a gyógyszerhatóanyag felfedezésétől a klinikai fejlesztésig – licencbe vehető projekteket keres.

Outline
The present invention relates to an absorbent intimate sanitary or hygiene product that is provided with a metal-based fiber (50) having antimicrobial activity. The antimicrobial fiber (e.g. silver fiber) protects against infections like antibacterial infections. The product may be a tampon kit, which comprises a tampon body (20), a withdrawal fiber (30) and a top sheet (70), covering at least a part of the outer surface of the tampon body (20), which is permeable to the metal particles. Preferably, a top sheet (70a) comprises or is made of antimicrobial metal-based fiber or a top sheet 70b has a probiotic effect. The thin fiber is typically arranged near to the intimate body surface-contacting surface, in parallel therewith, to provide a strong antibacterial effect when impregnated with a body fluid.

Outline
The present invention relates to an absorbent intimate sanitary or hygiene product that is provided with a metal-based fiber (50) having antimicrobial activity. The antimicrobial fiber (e.g. silver fiber) protects against infections like antibacterial infections. The product may be a tampon, having a body (20), an outer part (25) with the metal-based fibers and a withdrawal fiber (30), or a sanitary napkin or diaper with a similar arrangement. The thin fiber is typically arranged near to the intimate body surface-contacting surface, in parallel therewith, to provide a strong antibacterial effect when impregnated with a body fluid.

Outline
The present invention is an ultra-compact capillary electrophoresis (CE) device that can operate both independently and in connection with any mass spectrometer (MS) using a product-specific adapter that can be mounted on the CE device. This bioanalytical tool is suitable for CE-ESI-MS based analysis of different samples, it is compact, easy to use and robust in design, which is compatible with all types of mass spectrometers currently available on the market. The UCESI device (100) consists of a product-specific mounting frame (101), a thermostatable capillary module (102), an ESI port (103), a movable sample tray (104), and a serving unit (105).

Outline
Applying novel imipridone derivatives, containing 3,5-disubstituted benzyl group attached to position 7, being subject of the present invention, especially on patients suffering from prostate carcinoma, pancreatic cancer, lung carcinoma, breast cancer, glioma, cancers of head and neck, colon cancer, skin cancer proved to show enhanced anticancer activity. The present invention relates to compounds of formula (I) (I) or pharmaceutically acceptable salts, and stereoisomers thereof, which are applicable for use in treating cancer diseases. The present invention further relates to a pharmaceutical composition comprising the above compounds.

Outline
Mycoplasma anserisalpingitidis is a pathogen lurking in geese which poses a threat primarily to the health of geese and, less commonly, ducks. Inflammation and atrophy develop in the cloaca and genitals of infected animals, the number of fertile eggs decreases, eggshell formation is impaired, and embryo mortality increases. Stress, which is an inevitable part of animal husbandry, especially large-scale but also barnyard animal husbandry, greatly increases the susceptibility of animals to both infection and the development of severe symptoms. In addition to congestion, inadequate housing conditions and the behavioral changes (mocking) associated with the mating season are also sources of stress in the life of our geese. M. anserisalpingitidis is likely to be ubiquitous in all of the major goose-breeding areas of the world: it has also been detected in Hungary, China, France and Vietnam. Until now, there has not been a sufficiently reliable method available against infection: despite proper housing and handling conditions, it can appear in any yard. Our solution is a vaccine to prevent the development of infection and / or symptomatic disease. Immunization of animals is easy and effective because the vaccine can be delivered into the cloaca or even sprayed onto the deep litter. The production of the active substance and formulation of the vaccine does not require special technology.

Outline
The invention relates to the field of assessing transport activity of OATP (Organic anion-transporting polypeptide) transport proteins. In particular, the invention relates to a real-time, add-and-read fluorescence-based method for determining whether a test compound interferes with substrate transport activity of an OATP, by using a non-fluorescent control substrate which becomes fluorescent within a cell. The method is also applicable to measure the expression of an OATP and to discriminate between a transported substrate and an inhibitor of an OATP.

Outline
The invention relates to the field of assessing transport activity of OATP (Organic anion-transporting polypeptide) and ABC (ATP Binding Cassette) transport proteins. In particular, the invention relates to methods for determining in a single, fluorescence-based assay whether a compound is a modulator of OATP and/or MRP2 (Multidrug resistance associated protein, ABCC) transport activity, using a fluorescent compound that is a substrate of both OATP and MRP2, and is selected from sulfopyrenes having general formula (I) or sulforhodamines having general formula (II).

Outline
The invention relates to a polymeric indicator fixed in a polymeric gel carrier, wherein the polymeric gel carrier comprises a hydrophilic polymer, wherein the polymeric indicator and the hydrophilic polymer are present together in the form of a combined cross-linked hydrogel network fixed by chemical bonds. The invention further relates to a method for preparing a polymeric indicator fixed in a polymeric gel carrier and to a sensor for measuring pH, which comprises the polymeric indicator fixed in a polymeric gel carrier.