Tavanta Therapeutics Ltd. has a balanced approach to discovery and product development by (i) enhancing the clinical performance of established molecules and (ii) synthesizing novel small molecules and therapeutic peptides.
The current novel molecular DNA cloning procedure – during which a given DNA fragment (DNA stretch subjected to cloning, also called “insert”) aimed to be multiplied is introduced into a vector DNA (“vehicle”) without using in vitro added enzymes such as restriction endonucleases, ligases, DNA polymerases and 5′ exonucleases – is particularly suitable for generating novel DNA constructs in a relatively fast and cost-effective way, as it performs DNA cloning without using in vitro added enzymes.
Applying novel imipridone derivatives, containing 3,5-disubstituted benzyl group attached to position 7, being subject of the present invention, especially on patients suffering from prostate carcinoma, pancreatic cancer, lung carcinoma, breast cancer, glioma, cancers of head and neck, colon cancer, skin cancer proved to show enhanced anticancer activity.
Mycoplasma anserisalpingitidis is a pathogen lurking in geese which poses a threat primarily to the health of geese and, less commonly, ducks.
The invention relates to the field of assessing transport activity of OATP (Organic anion-transporting polypeptide) transport proteins. In particular, the invention relates to a real-time, add-and-read fluorescence-based method for determining whether a test compound interferes with substrate transport activity of an OATP, by using a non-fluorescent control substrate which becomes fluorescent within a cell. The method is also applicable to measure the expression of an OATP and to discriminate between a transported substrate and an inhibitor of an OATP.
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